Experimental models of scald burns. A scope review.

PURPOSE: To conduct a scope review of the experimental model described by Walker and Mason, by identifying and analyzing the details of the method. METHODS: The authors searched Pubmed-Medline, Cochrane-Bireme and PEDro databases for articles published between January 2016 and December 2018, using the following search queries: burns, burn injuries, models animal, and animal experimentation. All articles whose authors used Walker and Mason's model - with or without changes to the method in Wistar rats - were included in this study. RESULTS: The search identified 45 mentions of Walker and Mason's model; however, after reading each summary, 20 were excluded (of which 5 due to duplicity). The inconsistencies observed after the scope review were: water temperature, length of time of exposure of the experimental model's skin to water, extent of the burnt area, and the description of the thickness/depth of the injury. CONCLUSIONS: Reproducibility of a scientific method is the basis to prove the veracity of the observed results. Thus, it is necessary to have a greater number of publications that adopt a reproducible scientific method, for this review found inconsistencies in the description of Walker and Mason's model.

Experimental models of scald burns. A scope review

Abstract Purpose: To conduct a scope review of the experimental model described by Walker and Mason, by identifying and analyzing the details of the method. Methods: The authors searched Pubmed-Medline, Cochrane-Bireme and PEDro databases for articles published between January 2016 and December 2018, using the following search queries: burns, burn injuries, models animal, and animal experimentation. All articles whose authors used Walker and Mason's model - with or without changes to the method in Wistar rats - were included in this study. Results: The search identified 45 mentions of Walker and Mason's model; however, after reading each summary, 20 were excluded (of which 5 due to duplicity). The inconsistencies observed after the scope review were: water temperature, length of time of exposure of the experimental model's skin to water, extent of the burnt area, and the description of the thickness/depth of the injury. Conclusions: Reproducibility of a scientific method is the basis to prove the veracity of the observed results. Thus, it is necessary to have a greater number of publications that adopt a reproducible scientific method, for this review found inconsistencies in the description of Walker and Mason's model.

Infusão controlada de CO2 no tratamento de fibrose pós criolipólise / Controlled infusion of CO2 in fibrosis treatment after cryolipolysis

Introdução: A fibrose está associada à deposição excessiva de fibras da matriz extracelular, onde os fibroblastos são a principal fonte de produção de colágeno. Neste processo pode ocorrer uma disfunção e a produção de colágeno ocorrerá de forma desordenada. A infusão controlada de CO2 no tecido subcutâneo é um procedimento para fins terapêuticos visando a melhora dos sintomas de doenças inflamatórias e isquêmicas. Posteriormente, verificou-se que a infusão de CO2 através de agulhas melhorou não só a circulação sanguínea em tecidos isquêmicos, como aumentou o aporte de oxigênio localmente. O objetivo deste estudo foi avaliar a eficácia da aplicação da infusão controlada de CO2 em lesão fibrótica decorrente da aplicação de criolipólise. Métodos: Foi realizado um estudo descritivo. No relato em questão, a paciente apresentou fibrose na região tratada 15 dias após ter sido submetida à criolipólise. O tratamento proposto foi infusão controlada de CO2 associada à massagem Vibrocell®. Resultados: A partir da 5ª sessão foi observada redução do processo fibrótico. Conclusão: A associação dos procedimentos de infusão controlada de CO2 e Vibrocell® nos parâmetros apresentados neste relato de caso foram satisfatórios no tratamento da fibrose pós criolipólise com dissolução total após a 8ª sessão. (AU)

Introduction: Fibrosis is associated to excessive deposition of extracellular matrix fibers, where fibroblasts are the main source of collagen production. In this process the production of collagen can occur in disordered form. Controlled infusion of CO2 in the subcutaneous tissue is a procedure for therapeutic purposes aimed at improving the symptoms of inflammatory and ischemic diseases. Later, it was verified that CO2 infusion through needles not only improved the blood circulation in ischemic tissues, but also increased the oxygen supply locally. The objective of this study was to evaluate the efficacy of the controlled infusion of CO2 in fibrotic lesions due to cryolipolysis. Methods: A descriptive study was carried out. The patient presented fibrosis in the treated region 15 days after being submitted to cryolipolysis. The treatment was a controlled infusion of CO2 associated with Vibrocell® massage. Results: After the 5th session, the fibrotic process was reduced. Conclusion: The association of controlled infusion of CO2 and Vibrocell® in the parameters presented in this case were satisfactory in the treatment of fibrosis after cryolipolysis with total dissolution after the 8th session. (AU)